The relationship between the cAMP and β_2-adrenergic receptor genetic polymorphisms in asthmatics in the people of the Han nationality

Objective To analyze the association betweenβ 2 AR genetic polymorphism and cAMP in patients with asthma.Methods The 16,27 locus alleles of β 2 AR genetic polymorphisms were determined by using AS PCR techniques and the cAMP was determined by using RIA techniques in 44 patients with asthma.Results The relativity between cAMP and genotype β 2 AR 16 loci:the level of cAMP was (18.03±4.37)pmol/ml in Arg/Arg,(18.54±14.22)pmol/ml in Arg/Gly and(13.00±4.07)pmol/ml in Gly/Gly.There were significant difference cAMP compared with three groups;(15.99±4.89)pmol/ml in Gln/Gln genotype,(16.14±4.34)pmol/ml in Gln/Glu and(13.69±7.88)pmol/ml in Glu/Glu,There were no significant difference in cAMP compared with three groups in β 2 AR 27 loci.Conclusion β 2 AR 16 locus genetic polymorphism is correlated with cAMP in asthma.