Highly efficient ultrasound promoted synthesis of 2-phenylquinoxaline in glycerol-water.

INTRODUCTION Quinoxalines show diversified applications in the field of medicinal chemistry. MATERIALS AND METHODS Therefore, we have designed highly efficient, environmentally benign and one-pot protocol for the synthesis of 2-phenylquinoxaline from the reaction of Acetophenone, N-bromosuccinimide and 1,2-phenylenediamine under ultrasound irradiation in glycerol-water. RESULTS AND DISCUSSION We observed that, although the reaction efficiently completed in all of these solvents, the use of glycerol-water with different ratio give consistently higher yields (89-94%) and decrease reaction times. CONCLUSION The main advantages of this protocol are green method; avoid use of toxic catalyst and volatile organic medium and product obtained with excellent yield.