Chiral α,ω-diaminoethers derived from d-mannitol and l-treitol as building blocks for the synthesis of macrocyclic compounds possessing 1,3-benzenedicarboxamide or 2,6-pyridinedicarboxamide subunits

Abstract Three new chiral α,ω-diaminoethers, derivatives of d -mannitol and l -treitol, possessing C 2 symmetry are prepared. The α,ω-diaminoethers were applied to the macrocyclization reaction under non-high-dilution conditions, which afforded chiral macrocyclic diamides possessing either 2,6-pyridinedicarboxamide or 1,3-benzenedicarboxamide moieties.