A systematic review and meta-analysis of the association between shift work and metabolic syndrome: The roles of sleep, gender, and type of shift work

This study was conducted to investigate the association between shift work and metabolic syndrome (MetS) and quantify the roles of sleep, gender, and type of shift work. We searched online databases, including PubMed, Scopus, and Web of Science on November 17, 2019. Of the 821 articles identified, 38 observational studies (27 cross-sectional, 10 cohorts, and one nested case-control), conducted on 128,416 participants, met our eligibility criteria. The pooled Odds ratio (OR) and 95% Confidence interval (CI) of MetS in shift-versus day-workers were estimated as 1.14 (1.07, 1.21) and 1.11 (1.06, 1.17) for the unadjusted and adjusted models. This association remained significant only for the studies with a cross-sectional design. There was a significantly higher odds of MetS in the studies conducted only on females (1.13 [1.06, 1.20]) or males (1.12 [1.02, 1.21]). The pooled adjusted OR (95% CI) for the studies without and with sleep adjustment was calculated as 1.14 (1.08, 1.21) and 1.29 (1.06, 1.52). We observed that rotating shift workers had stronger odds of MetS than the other shift workers. In conclusion, our findings revealed the significant odds of an association between shift work and MetS and different effects for sleep, gender, and type of shift work.