SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF CO-ORDINATION POLYMERS

A novel heteronuclear bis-ligand namely 5-(4-(2-carboxyphenyl carbonyl amino)-phenyl-4-carbonyl methyl amino)-8-hydroxyquinoline was synthesized and characterized. This Bis-ligand was designated as CPHQ. Co-ordination polymers of this CPHQ bis-ligand were prepared with Cu+2, Co+2, Ni+2, Mn+2 and Zn+2 metal ions. All of these Co-ordination polymers and the CPHQ ligand were characterized by elemental analysis, IR, NMR spectral studies, thermogravimetry, electronic reflectance spectral studies and magnetic susceptibility measurement. The synthesized novel Bis-ligand and their Co-ordination polymers were screened for their antimicrobial activity. 1,2 . Recently new coordination supramolecules and polymers bis(oxine), bidentate ligand based on transition metal compounds and multidentate organic ligand has attracted much interest. In this context bis(oxine) ligand with two oxine units link by a bridge of 5,5'- methylene (-CH2- ), 5,5'-sulfonyl (-SO2-), 5,5'-dimethylene sulfide (-CH 2-S-CH2-) and -CH2- O-CH2- are reported in literature 3-9 . Most of bichelating ligands are derived from well known chelating agents like 8-hydroxy quinoline and salicylic acid etc 3,6 . 8-Hydroxyquinoline (8-HQ) moiety has received constant consideration due to their efficient ionophores, therapeutic and fluorescences properties 10-14 . 8-Hydroxyquinoline containing polymers are used in areas such as waste water treatment to recover metals, protective coatings, water disinfectants, ion-exchange resin, antifouling paints, antimicrobial, surgical materials, gels and ointment for medical uses 15-21 . 8-Hydroxyquinoline containing polymers and copolymers reveal complexing ability and biological activity 22-25 . The study of 8-quinolinol containing polyester has also been reported 26 . The area in which the Co-ordination polymers having bis-azo dye containing ligands has not been developed so far. Such ligand may afford the Co-ordination polymer with different properties. Hence, it was thought interesting to explore the field of Co-ordination polymers based on hetronuclearting Bis-ligand having 8-hydroxyquinoline and amic acid. Though the amic acid is generally derived by condensation of amines with anhydrides having carboxylic and amide group. The metal complexation study of various amic acids has been reported recently 27-30 , so the proposed present work is in connecting with the Co-ordination polymers based on hetronuclearting Bis-ligand. The synthetic route for the preparation of bis-ligand and its Co-ordination polymers are shown in scheme 1.