Structural brain changes in patients with rheumatoid arthritis
2009
Introduction: Recent studies demonstrated that chronic pain leads
to possible structural brain changes in diseases such as lower back
pain, migraine and fibromyalgia. We used two automated methods
to investigate whether morphometric changes occur in patients
with rheumatoid arthritis (RA).
Methods: We recruited 28 patients with severe RA, and 25 age- and
sex-matched healthy controls. High-resolution MP-RAGE images
were acquired on a 3T scanner Tim Trio (Siemens, Erlangen).
Data were analyzed using FSL_VBM, a voxel-based morphometry
style analysis and FreeSurfer, a surface-based morphometry. To
investigate the effect of disease duration, a model with disease
duration as a regressor of interest was used in the patients group.
Results: There were no local structural grey-matter differences
between patients and controls in the FSL_VBM. The FreeSurfer
analysis however revealed decrease in grey-matter thickness in
both parahippocampal gyri. Moreover, RA patients had significantly
smaller brains compared to controls, estimated using intracranial
volume (ICV). In the patient group, disease duration,
when controlled for age, significantly correlated with ICV (r = 0.44
p = 0.019) and there was a trend for ASF (r = −0.36 p = 0.055).
Furthermore, in the patients group the disease duration regressor
negatively correlated with grey matter density in the thalamus.
Conclusions: These results suggest that there are global brain
differences associated with RA. However, it is not clear whether
these changes represent an accelerated rate of atrophy as
observed in fibromyalgia, the effect of systemic inflammation and
vasculopathy similar to lupus erythrematosus or rathe
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