Fast inactivation of a brain K channel composed of Kv1
1999
Quinoline derivatives, especially those of the formula wherein X represents halogen, nitro or CF3, Z represents hydrogen, alkyl or aryl, Y represents hydrogen, OH, CN, COR or SO3H, R represents alkyl, alkoxy or aryl and n represents an integer from 0 to 4, are obtained in high yields when corresponding aromatic orthodichloromethyl isocyanates are converted by hydrolysis and decarboxylation into the corresponding ortho-aminoaldehydes and these are subjected to a condensation reaction with carbonyl compounds containing an active alpha -methylene group. The process products are starting materials for dyestuffs, insecticides and others.
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