The Study of the Content of N-Acetylneuraminic Acids in Membranes of Erythrocytes in Patients with Glaucoma
2017
The aim of this work was to study the content of total and
lipid-bound neuraminic (sialic) acid in erythrocyte
membranes in patients with glaucoma. The results of our
studies showed that glaucoma is accompanied by an
increase in the total content of neuraminic acid obtained
from glycoproteins and glycolipids. A study of the content
of gangliosides made it possible to detect a decrease in all
fractions of gangliosides, which is associated with the
hydrolytic breakdown of gangliosides and with the
increase of free neuraminic acid. The data obtained are
interpreted in connection with the destruction of
membranes, leading to a disruption of cellular functions.
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