Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder

Patients with obsessive-compulsive disorder (OCD) have attenuated reward anticipatory activity in the nucleus accumbens (NAc), and deep brain stimulation (DBS) of the NAc is used to treat OCD. The authors show that NAc DBS normalizes NAc activity, reduces connectivity between NAc and prefrontal cortex, and decreases frontal low-frequency oscillations in OCD patients.