1‐Aryl‐3,4‐dihydro‐1H‐quinolin‐2‐one Derivatives, Novel and Selective Norepinephrine Reuptake Inhibitors.

A novel series of 1-aryl-3,4-dihydro-1H-quinolin-2-ones have been discovered as potent and selective norepinephrine reuptake inhibitors. Efficient synthetic routes have been developed which allow for the multi-gram preparation of both final targets and advanced intermediates for SAR expansion.