FR901469, a Novel Antifungal Antibiotic from an Unidentified Fungus No.11243 : I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Properties

FR901469 is a novel antifungal antibiotic produced by an unidentified fungus No.11243. This compound was isolated from the culture broth by solvent extraction, HP-20 and YMC ODS gel column chromatography, and lyophilization. FR901469 is a white powder which melts at 182-187°C and possesses the molecular formula C71H116N14O23. This compound has good water solubility. FR901469 inhibited the activity of 1, 3-β-glucan synthase from Candida albicans with an IC50 value of 0.05μg/ml, and displayed greater inhibitory activity than other 1, 3-β-glucan synthase inhibitors such as, WF11899A, echinocandin B, aculeacin A, and papulacandin B.