Synthesis of Lanso Aminopyrimidines as Dominant Chemotherapeutic Agents for Leukaemia

In the present paper we synthesized 10 unique pyrimidine scaffolds (Lanso Aminopyrimidines) derived from 4-(2,2,2-trifluoroethoxy)-2-(chloromethyl)-3-methylpyridine as a core molecule, which can be used for the design of more potent and effective anticancer agents. The in vitro anticancer activities of the synthesized new pyrimidine derivatives were screened at the National Cancer Institute, USA, against a full NCI 60 cell lines. Most of the compounds exhibited remarkable growth inhibition at a single dose (10 µM) in Leukaemia cancer cell. 4-(4-{3-Methyl-4-[(2,2,2-trifluoroethoxy)pyridin-2-yl]methylamino}phenyl)-6-phenyl-1,6-dihydropyrimidin-2-amine which showed high activity against RPMI-8226 leukaemia cancer cells (GI50 35.50 µM) and can be considered as a candidate lead compound for developing new promising anticancer agents.