(±)-Meliviticines A and B: Rearranged Prenylated Acetophenone Derivatives from Melicope viticina and Their Antimicrobial Activity
2019
Abstract Two new prenylated acetophenone derivatives racemates, meliviticines A ( 1 ) and B ( 2 ) with unprecedented rearranged skeletons, were isolated from Melicope viticina . Subsequent chiral resolution led to the separation of two pairs of enantiomers, (±)-meliviticines A ( 1a / 1b ) and (±)-meliviticines B ( 2a / 2b ). Their structures including absolute configurations were elucidated by extensive spectroscopic data, electronic circular dichroism analysis, and X-ray crystallography. A plausible biosynthetic pathway of 1 and 2 , involving ring cleavage and rearrangement of the prenylated acetophenone backbone was proposed. All the isolates showed moderate antimicrobial activities with MIC values of 25–50 μ g/mL against several bacterial and fungal strains.
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