LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling

Xiaomeng Wang,Sabu Abraham,Jenny A. G. McKenzie,N Jeffs,Matthew Swire,Vineeta B. Tripathi,Ulrich F. O. Luhmann,Clemens Lange,Zhenhua Zhai,Helen M. Arthur,James W B Bainbridge,Stephen E. Moss,John Greenwood

LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling

2013

Xiaomeng Wang
Sabu Abraham
Jenny A. G. McKenzie
N Jeffs
Matthew Swire
Vineeta B. Tripathi
Ulrich F. O. Luhmann
Clemens Lange
Zhenhua Zhai
Helen M. Arthur
James W B Bainbridge
Stephen E. Moss
John Greenwood

LRG1 is identified as a new regulator of TGF-β signalling that promotes angiogenesis via a TβRII–ALK1–ENG–Smad1/5/8 signalling pathway; antibody-mediated inhibition of LRG1 reduces pathogenic neovascularization in a mouse model of retinal injury.

Keywords:

Cell biology
Endoglin
Hedgehog signaling pathway
Angiogenesis
LRG1
Neovascularization
Regulator
Signal transduction
Transforming growth factor
Immunology
Biology
Angiogenic Switch
Choroidal neovascularization
Cancer research

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