Predictive Potential of Head and Neck Squamous Cell Carcinoma Organoids

Summary: In this issue of Cancer Discovery , Driehuis and colleagues establish culture conditions for the rapid, efficient, and long-term expansion of healthy human oral mucosa and head and neck squamous cell carcinoma (HNSCC) tumor organoids. The HNSCC tumor organoids provide a functional platform for analyzing tumor cell phenotype, tumorigenic potential, and drug and radiotherapy response, and they have a potential role in clinical decision-making. See related article by Driehuis et al., p. 852 .