Recognition of lysosomal glycosidases in vivo inhibited by modified glycoproteins

PURIFIED liver lysosomal glycosidases display very short plasma survival times following intravenous injection. The mechanism by which these hydrolases are cleared from plasma involves specific recognition of the enzymes by way of sites associated with the enzyme molecules. In our study, a modified plasma glycoprotein terminating in N-acetyl-glucosamine has been shown to inhibit recognition and clearance of several purified lysosomal glycosidases.