Clinicopathologically comparative analysis of perirenal angiomyolipoma and liposarcoma

Objective　To compare the clinicopathological features, differential diagnosis and treatment between perirenal angiomyolipoma (AML) and liposarcoma. Methods　Eleven cases of AML and thirty-nine cases of liposarcoma around the kidney from Peking University International Hospital from January 2015 to December 2020 were reviewed in terms of clinical manifestations, imaging examination, pathological morphology, immunophenotype and treatment follow-up. Results　The tumors in both groups were close to the kidney, and the imaging signs of renal defect were not distinctive enough to diagnose correctly. Perirenal AML was mainly female (P=0.003), the age of onset was younger than liposarcoma (P 0.05). Conclusions　Retroperitoneal perirenal AML and liposarcoma have similar imaging features, and gender, age, tumor number, primary/recurrent character, histomorphology, protein expression and gene amplification detection are helpful to differentiate them. Liposarcoma needs more extensive resection, active treatment and follow-up. DOI: 10.11855/j.issn.0577-7402.2021.08.08