Optimization of azepanone calcitonin gene-related peptide (CGRP) receptor antagonists: development of novel spiropiperidines.

Christopher S. Burgey,Craig M. Potteiger,James Z. Deng,Scott D. Mosser,Christopher A. Salvatore,Sean Yu,Shane Roller,Stefanie A. Kane,Joseph P. Vacca,Theresa M. Williams

Optimization of azepanone calcitonin gene-related peptide (CGRP) receptor antagonists: development of novel spiropiperidines.

2009

Christopher S. Burgey
Craig M. Potteiger
James Z. Deng
Scott D. Mosser
Christopher A. Salvatore
Sean Yu
Shane Roller
Stefanie A. Kane
Joseph P. Vacca
Theresa M. Williams

Several novel spiropiperidine-based CGRP receptor antagonists have been developed that maintain good potency and have reduced potential for metabolism.

Keywords:

CGRP receptor
Calcitonin gene-related peptide
Biochemistry
Metabolism
Antagonist
Chemical synthesis
Potency
In vitro
Lactam
Chemistry

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