Pyrazole-O-glucosides as novel Na+-glucose cotransporter (SGLT) inhibitors
2003
Abstract O -glucuronides and O -glucosides of a series of pyrazoles analogues were synthesized and evaluated for their SGLT inhibitory activity in brush border membrane vehicles (BBMVs) of rat kidney. O -glucosides of certain pyrazole analogues inhibited the transport of [ 14 C]-glucose in BBMVs, and induced glucosuria in Wistar rats by intravenous injection.
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