Sexual dysfunction in Drug- Naïve First Episode nonaffective Psychosis patients. Relationship with prolactin and psychotic symptoms. Gender differences.

Abstract Background Our aim is to examine differences in sexual functioning (SF) between patients with drug-naive first episode psychosis (FEP) and healthy controls (HC). We will also examine correlations between prolactin levels, testosterone levels and psychotic symptomatology with SF from a gender perspective. Methods Cross-sectional study. We included 68 FEP patients and 50 HC. A blood sample was extracted. We used the Positive and Negative Syndrome Scale to assess symptom severity, using the five factor structure according to Emsley. The Changes in Sexual Function Questionnaire (CSFQ) was administered. Results We found significantly better SF in HC than in patients (in CSFQ total score (p=0.032) and in CSFQ Desire (p=0.032)). A significant correlation between prolactin or testosterone and SF was not observed. We found a negative significant correlation between the disorganised subscale of the EMSLEY and total CSFQ (p=0.027; r=-0.329), CSFQ Desire (p=0.028; r=-0.329) and CSFQ Arousal (p=0.026; r=-0.332) in the patient sample. In a regression model, we found sex (p=0.003) and disorganized symptoms (p=0.034) as significant predictors. Conclusions We found evidence for better SF in HC than in FEP patients. We could not confirm an association between prolactin or testosterone and SF. Disorganized symptomatology could be a relevant factor in SF.