Evaluation of a Potential Clinical Significant Drug-Drug Interaction between Digoxin and Bupropion in Cynomolgus Monkeys

Yang Shen,Yang Yu,Wei Lai,Shuai Li,Zixuan Xu,Jiejing Jin,Xia Yan,Han Xing,Xijing Chen,Aizhen Xiong,Chunhua Xia,Jiake He,Kui Hong

Evaluation of a Potential Clinical Significant Drug-Drug Interaction between Digoxin and Bupropion in Cynomolgus Monkeys

2019

Yang Shen
Yang Yu
Wei Lai
Shuai Li
Zixuan Xu
Jiejing Jin
Xia Yan
Han Xing
Xijing Chen
Aizhen Xiong
Chunhua Xia
Jiake He
Kui Hong

Purpose A three-period digoxin-bupropion drug-drug interaction study was performed in cynomolgus monkeys to assess the effect of bupropion and its metabolites on digoxin disposition.

Keywords:

Bupropion
Biochemistry
Drug-drug interaction
Disposition
Chemistry
Pharmacology
Digoxin
Pharmacy
pharmacology toxicology

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