The Role of Typological Characteristics of Higher Nervous Activity in Rats in the Neurobiological Effects of Combined Exposure to an Antiorthostatic Suspension, γ-Rays, Protons, and Carbon 12C Ions

The study of the role of typological characteristics of higher nervous activity of rats in the neurobiological effects (rat behavior and its neurochemical mechanisms) of combined exposure to a 10-day antiorthostatic suspension, γ-, and high-energy proton and carbon ion (12C) irradiation demonstrated that the 12C ion irradiation caused more marked distortion of the ratio of orientation and exploratory behavior and passive defensive behavior/anxiety in rats of the excitable anxious emotional type. In the experiment with proton irradiation, the differences between typological groups were more smoothed out, though some parameters of passive defensive behavior in the rats of the experimental groups were also increased. These changes were accompanied by decreased monoamine metabolism in the prefrontal cortex.