First Total Synthesis and Absolute Configuration of Marine Cembrane Diterpenoid (+)-11,12-Epoxysarcophytol A.

A concise and efficient total synthesis of (+)-11,12-epoxysarcophytol A (1), an epoxy cembrane diterpenoid from marine soft coral Lobophytum, is described, which allows the assignment of an absolute configuration (11S,12S) of the epoxide function unambiguously.