Relationship between quality of platelet concentrate and platelet recovery rate of leukocyte removal filter.

We studied the effect of the quality of platelet concentrate (PC) on the recovery rate of leukocyte removal filters in platelet transfusion.Apheresis PCs taken in our hospital were stored in two types of storage bags (polyvinylchloride bag and polyolefin bag) for 48 to 96h. PC quality was analysed using GMP140-positive rate and pH level as parameters. Under the storage conditions employed, PCs showed a wide distribution of parameters, with pH ranging from 5.82 to 7.39 and GMP140-positive rate from 6.8% to 96.3%. The PCs were filtered with a leukocyte removal filter and then platelet recovery rate was measured.A significant correlation was found between PC quality (pH level and GMP140-positive rate) and platelet recovery rate, with velves of Y=9.107X+18.618, r=0.345 (p<0.05) and Y=-0.199X+89.487, r=0.498 (p<0.01). A significant correlation was also found between the indicators of PC quality (pH level and GMP140-positive rate), with r=0.662 and p<0.0001.These findings indicate that a deterioration in PC quality strongluy affects the platelet recovery rate off the leukocyte-removal filter.