Production derivatives of substituted thiazolizinedione and pharmaceuticals containing the same

PROBLEM TO BE SOLVED: To obtain a new thiazolizinedione derivative useful as antilipemic and antihypertensive agent. SOLUTION: This compound is obtained by carrying out the reaction of the compound of formula I (A 1 is an aromatic heterocyclic ring; R 1 is H, an alkyl, an acyl, an aralkyl, etc.; R 2 and R 3 are each H or R 2 joins R 3 in forming a bond; A 2 is a substituted benzene ring; (n) is 2-6) with the compound of formula II (R a is expressed in formula III) and a proper reagent capable transforming R a to formula III. This reagent is a compound expressed in the formula A 1 -R x (R x is a leaving group), allowing to react with the compound of formula II in a solvent such as THF, etc., at 0-60°C. 5-(4-[2-(N-methyl-N-(2-benzothiazolyl) amino)-ethyoxy]benzyl)-2,4-thiazolizinedione is exemplified as the compound of formula I. The applying dose of the compound of formula I is 0.1-6,000mg preferably 1-1,500mg for a day for adult of 70kg weight. COPYRIGHT: (C)1997,JPO