Doxorubicin-Conjugated Platinum Theranostic Nanoparticles Induce Apoptosis via Inhibition of a Cell Survival (PI3K/AKT) Signaling Pathway in Human Breast Cancer Cells

Puja Patel,Vinita Manimaran Nadar,Devan Umapathy,Selvambigai Manivannan,Rajiu Venkatesan,Velanganni Antony Joseph Arokiyam,Srinivasan Pappu,Pitchan Arul Prakash,Mohamed Sultan Mohamed Jabir,Balázs Gulyás,Parasuraman Padmanabhan,Subramanian Tamil Selvan,Ponnuchamy Kumar

Doxorubicin-Conjugated Platinum Theranostic Nanoparticles Induce Apoptosis via Inhibition of a Cell Survival (PI3K/AKT) Signaling Pathway in Human Breast Cancer Cells

2020

Puja Patel
Vinita Manimaran Nadar
Devan Umapathy
Selvambigai Manivannan
Rajiu Venkatesan
Velanganni Antony Joseph Arokiyam
Srinivasan Pappu
Pitchan Arul Prakash
Mohamed Sultan Mohamed Jabir
Balázs Gulyás
Parasuraman Padmanabhan
Subramanian Tamil Selvan
Ponnuchamy Kumar

Herein, we report facile theranostic platinum nanoparticles (PtNPs) conjugated to an anticancer drug, doxorubicin (DOX), in unraveling the inhibition of a cell survival PI3K/AKT (phosphatidylinosit...

Keywords:

theranostic nanoparticles
Apoptosis
Cancer cell
Platinum
pi3k akt signaling
Chemistry
Cancer research
cell survival
Doxorubicin
Conjugated system

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