Synthesis and evaluation of substituted 4-alkoxy-2-aminopyridines as novel neuropeptide Y1 receptor antagonists.

Abstract A series of substituted 4-alkoxy-2-aminopyridines 2 , which were formally derived from neuropeptide Y1 antagonist 1 by replacing the morpholino portion with alkoxy groups, were synthesized and evaluated as neuropeptide Y Y1 receptor antagonists. Primary structure–activity relationships and identification of potent 4-alkoxy derivatives are described.