Effect of levamisole on the formation of agglutinins against salmonellosis in weaned lambs

: In order to follow up the effect of levamizol on the titer of agglutinins a killed vaccine of Salmonella abortus ovis; S. enteritidis, and S. typhimurium strains was used under protection of antidenaturating agents (80 per cent sac charose) and levamizol ICI at the rate of 10 mg per kg body mass. Experiments were carried out with a total of 20 rabbits and 36 weaned lambs, divided into groups and injected with vaccine, vaccine and levamizol simultaneously, vaccine with levamizol following on the 3rd day, and vaccine and levamizol following on the 7th day, respectively. Results obtained by means of slow agglutination and hemagglutination showed that agglutinins had highest titers in the groups that received vaccine and levamizol simultaneously. The changes established with histologic investigations of the rabbits confirmed the importance of the simultaneous application of vaccine and levamizol for the immunologic 'reconstruction' of the body. Immunoelectrophoretic investigations concerning the globulins of the various groups did not point to essential differences having anything to do with the use of levamizol.