Fibrinogen Dysregulation is a Prominent Process in Fatal Conditions of COVID-19 Infection;a Proteomic Analysis

Introduction: Molecular pathophysiology of COVID-19 is not completely known Expression changes in patients' plasma proteins have revealed new information about the disease Introducing the key targeted plasma protein in fatal conditions of COVID-19 infection is the aim of this study Methods: Significant differentially expressed proteins (DEPs) in the plasma of cases with a fatal condition of COVID-19 were extracted from an original article These proteins were included in a network via STRING database along with 100 first neighbor proteins to determine central nodes of the network for analyzing Results: Queried and added proteins were included in a scale free network Three hub nodes were identified as critical target proteins The top queried hub proteins were chains of fibrinogen;Fibrinogen Alpha chain (FGA), Fibrinogen gamma chain (FGG), and Fibrinogen beta chain (FGB), which are related to the coagulation process Conclusion: It seems that fibrinogen dysregulation has a deep impact on the fatality of COVID-19 infection