Pt(II), Pd(II) and UO2(II) complexes of N,N′-bis(2-pyridyl)thiourea; structural, thermal and biological studies

Abstract Novel complexes of Pt 2+ , Pd 2+ and UO 2 2+ with N,N ′-bis(2-pyridyl)thiourea (H 2 BPT) 1 were synthesized. These complexes namely [Pt(HBPT) 2 ] 2 , [Pd(HBPT) 2 ] 3 and [UO 2 (HBPT)(OAc)(H 2 O)] 4 , were characterized by elemental analysis and spectral measurements. Suggested structures (square-planar for both 2 and 3 complexes and pentagonal-bipyramidal geometry for 4 ) were confirmed by applying geometry optimization and conformational analysis. Thermal properties and decomposition kinetics of all compounds are investigated. The interpretation, mathematical analysis and evaluation of kinetic parameters ( E, A, ΔH , ΔS and ΔG ) of all thermal decomposition stages have been evaluated using Coats–Redfern, Horowitz–Metzger and MKN methods. The biochemical studies showed that, complex 2 has powerful and complete degradation effect on DNA. The antibacterial screening demonstrated that, complex 2 has the maximum and broad range activities against Gram-positive and Gram-negative bacterial strains.