19F-NMR-based determination of the absorption, metabolism and excretion of the oral phosphatidylinositol-3-kinase (PI3K) delta inhibitor leniolisib (CDZ173) in healthy volunteers

David Pearson,Maxime Garnier,Alexandre Luneau,Alexander-David James,Markus Walles

19F-NMR-based determination of the absorption, metabolism and excretion of the oral phosphatidylinositol-3-kinase (PI3K) delta inhibitor leniolisib (CDZ173) in healthy volunteers

2018

David Pearson
Maxime Garnier
Alexandre Luneau
Alexander-David James
Markus Walles

Abstract1. Leniolisib is a novel oral phosphatidylinositol-3-kinase (PI3K) delta inhibitor, currently in clinical development for the treatment of inflammatory and autoimmune diseases.2. We investi...

Keywords:

Fluorine-19 NMR
Absorption (pharmacology)
PI3K/AKT/mTOR pathway
Metabolism
Excretion
Biochemistry
Phosphatidylinositol
Chemistry
Kinase
Delta

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations