Characterization of two rat models of cystic fibrosis—KO and F508del CFTR—Generated by Crispr‐Cas9
2019
Background
Genetically engineered animals are essential for gaining a proper understanding of the disease mechanisms of cystic fibrosis (CF). The rat is a relevant laboratory model for CF because of its zootechnical capacity, size, and airway characteristics, including the presence of submucosal glands.
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