Hirsutella sinensis Attenuates Aristolochic Acid-Induced Renal Tubular Epithelial-Mesenchymal Transition by Inhibiting TGF-β1 and Snail Expression

Xiao-yi Xu,Jing-jing Chai,Yi-pu Chen,Hong-liang Rui,Yan-yan Wang,Hong-rui Dong,Yu-Lin Man,Hong Cheng

Hirsutella sinensis Attenuates Aristolochic Acid-Induced Renal Tubular Epithelial-Mesenchymal Transition by Inhibiting TGF-β1 and Snail Expression

2016

Xiao-yi Xu
Jing-jing Chai
Yi-pu Chen
Hong-liang Rui
Yan-yan Wang
Hong-rui Dong
Yu-Lin Man
Hong Cheng

Objective To investigate the inhibitory effect of Hirsutella sinensis (HS) on epithelial-mesenchymal transition (EMT) of renal tubular epithelial cells induced by aristolochic acid (AA) and its possible mechanism.

Keywords:

Regulation of gene expression
Hirsutella
Snail
Molecular biology
Aristolochic acid
Transforming growth factor
Epithelial–mesenchymal transition
Botany
Keratin 18
Biology
Cell culture
Transfection

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