Aqueous extract of solanum nigrum activated programmed cell death and enhanced cisplatin/doxorubicin induced cytotoxicity on human hepatocellular carc

Results: The treatment of Centella spp. revealed significant reduction of lipid droplet deposition anddecrease of the size of lipid droplet in the adipocyte. Molecular biological experiment suggested that the treatment of Centella spp. significantly inhibited the expression of Trib 3: more than 100% of Trib3 was decreased compared to the control. On the contrary, the express ion of adiponectin, CTRP 6 and Glut 4 were considerably increased by the treatment of these herbal extracts. Conclusion: These results suggest that the adaptation of these herbal extracts have significant potential to inhibit fatal etiological triggering of cardiovascular disease causing by the obesity. Hence, these herbal extract might be a therapeutic target to fight against obesity and its associated diseases in modern industrial countries. Contact: JunLae Cho, junlae.cho@sydney.edu.au