Crystallized structure of aurora-2 protein and its union pockets.

A crystal belonging to the spatial group P3221 and having unit cell parameters of a = b = 87 ± 2A, c = 76 ± 2 A; α, β = 90 ° and γ = 120 °, comprising a molecule or molecular complex comprising amino acid residues 107-403 of SEQ ID NO: 1 of a non-phosphorylated Aurora -2 protein kinase according to Figure 1, 2 , 3 or 4, where the mean quadratic deviation of the skeletal atoms between the amino acid residues of said molecule or molecular complex and said amino acid residues of Aurora-2 is not greater than 5 A.