A Controlled Clinical Trial of Alprazolam for the Treatment of Anxiety

METHOD The authors report the results of a large-scale double-blind study comparing the anxiolytic effects of aiprazolam, a triazolobenzodiazepine; diazepam, a 1 ,4-benzodiazepine; and placebo in I 51 anxious outpatients. Alprazolam and diazepam produced similar clinical improvement, which was significantly larger than improvement produced by placebo and was clearly evident after only 1 week of treatment. The incidence of sedation was lower with alprazolam than with diazepam. (Am J Psychiatry 140:82-85, 1983)