studies on interaction of metal ions with 6- f1uoro-7-(5-nonyl-l ,3,4-oxadiazol-2- ylsulphanyl)-4-quinolone-3-carboxylic acid (QDA)

Formati o n constants of Cu, Ni , Co, Z n, Mn and Mg with 6fluoro- 7 -(S- nonyl- I ,3,4-oxadiazol-2-y Isulphanyl)-4-quinolone-3carboxyli c ac id have been determined using BEST program. Species d istrib uti o n is plotted us ing programs BEST a nd SPE whi ch indi cates th at at bi o logical p H valu e, complex formati o n is tak in g place with Mg. Mo lecul a r mechanics calcul ati o ns a lso confirm th e complexatio n behaviour of th e li ga nd . This suppo rt s th e explanati on of antibac terial mecha ni sm th ro ugh complexati o n o f drug with Mg of bacterial DNA.