A novel near-infrared fluorescent probe for detection of early-stage Aβ protofibrils in Alzheimer's disease.

Detection of Aβ protofibrils at the early stage of Alzheimer’s disease was realized by a novel near-infrared probe (DCM-AN) based on dicyanomethylene-4H-pyran. This probe exhibits high affinity towards Aβ protofibrils in vitro and in brain sections of transgenic mouse models for Alzheimer’s disease.