Synthesis technology of pyraclostrobin

2016 
The invention provides a synthesis technology of pyraclostrobin. The method comprises the following steps that1, ortho-nitrotoluene and NH4Cl are subjected to a reduction reaction under the catalytic action of zinc powder and alloy micro-nano powder; 2, hydroxylamine is subjected to an acylation reaction; 3, a methylation reaction is performed; 4, a bromination reaction is performed to obtain N-methoxy-N-2-methyl bromide methyl phenyl carbamate; 5, DMF is used as a solvent for dissolving the N-methoxy-N-2-methyl bromide methyl phenyl carbamate to prepare a solution for use, 1-(4-chlorphenyl)-pyrazol alcohol, K2CO3 and acetone are placed into a reactor together, heating and reflux are performed, the N-methoxy-N-2-methyl bromide methyl phenyl carbamate solution is added into the reactor slowly, and after the reflux reaction is ended, pyraclostrobin is obtained. Compared with the prior art, the preparation method is simple, raw materials are low in cost and easy to obtain, the reaction conditions are mild, and the obtained target product is high in purity and yield.
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