Фолликуло- и оогенез: химические свойства и биологическое действие лютеинизирующего гормона

According to the accepted two-cellular concept of the ovarian steroidogenesis, under the influence of LH there is a transformation of cholesterol into androgens, which, penetrating in granulose, under the influence of aromatase are transformed to an estrogen. Emergence of receptors to LH in granulose is noted only in achievement by a growing follicle of diameter more than 10 mm, that is accompanied by sharp strengthening of the production of an estrogens in this follicle and braking of synthesis of FSH by a hypophysis. In the ripening follicles which haven’t reached 10 mm in the diameter, there is a braking of conversion of androgens in an estrogen that promotes their atresia. Sufficient production of endogenous LH underlies selection of a leading follicle, final maturing of an oocyte and an ovulation.