Comparing Short-Duration Electro-Oculograms with and without Mydriasis in Healthy Subjects Vergleich eines kurzzeitigen Elektro-Oculograms mit und ohne Mydriase bei gesunden Probanden

Abstract ! Background: In order to obtain artifact-free elec-tro-oculogram recordings the subject ʼs coopera-tion is necessary. The aim ofour study is to evalu-atetherecordingcharacteristicsofshort-durationEOG and to compare the effect of mydriasis onelectro-oculogram recordings in a cohort of con-trols. Patients and Methods: Electro-oculogram re-cordings were performed on a light-emitting di-ode stimulus screen using a RETI-port gammaplus 2 system (RETIscan ™, Roland Consult). Fastoscillations were set at 1.5sec (6 cycles; total du-ration75sec).Thedarkphaseincluded:pre-adap-tation (6min), alternatefixation (4min), fixation-rest (20sec), 100 sweeps. The light phase in-cluded: light adaptation (4min), alternate fixa-tion (10min), fixation-rest (20sec), 250 sweeps.The amplifier band pass was filtered at 0.1÷50Hz. The background illumination in mydriasiswas 100cd/m 2 and in miosis – 450cd/m 2 . Results: A total of 55 controls participated andwere divided into three age groups [number;mean (years, y);±SD]: group 1: 18 –20 years (19;19.49 years; ±0.89); group 2: 20 –40 years (18;27.91 years; ±5.39) and group 3: 40 –60 years(18; 48.66 years; ±4.00). The Arden ratio, dark-trough and light-peak did not differ between re-cordings with or without mydriasis (p=0.914;p=0.880; p=0.680, linear mixed-effects model).The age did not influence the Arden ratio, dark-trough, light-peak (p=0.206; p=0.112; p=0.155). Arden ratio, dark-trough, light-peak werecomparable between tested eyes (p=0.934;p=0.193; p=0.270).