Maintenance of muscle stem-cell quiescence by microRNA-489

Tom H. Cheung,Navaline L. Quach,Gregory W. Charville,Ling Liu,Lidia Park,Abdolhossein Edalati,Bryan Yoo,Phuong T Hoang,Thomas A. Rando

Maintenance of muscle stem-cell quiescence by microRNA-489

2012

Tom H. Cheung
Navaline L. Quach
Gregory W. Charville
Ling Liu
Lidia Park
Abdolhossein Edalati
Bryan Yoo
Phuong T Hoang
Thomas A. Rando

Adult muscle stem cells are used as a model system to show that the microRNA pathway, and specifically miR-489, is essential for the maintenance of the quiescent state of an adult stem-cell population by suppressing a key proliferation factor, Dek.

Keywords:

Regulation of gene expression
microRNA
Myocyte
Cellular differentiation
Stem cell
Cell cycle
Population
Cell biology
Biology
Ribonuclease III
Cell division
Progenitor cell

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

342

Citations