Oxidative Phosphorylation of N-Aryl Glycine Amides via sp3 C−H Functionalization

An efficient phosphorylation of various glycine amides has been developed for radical cation salt-induced C−H functionalization, producing a series of α-aminophosphonates in high yields. Different from reported approaches, trialkyl phosphite was chosen as the phosphorus nucleophile, and the scope investigation shows broad functional group tolerance and high efficiency of the oxidative phosphorylation. This method provides a new way to synthesize α-aminophosphonates.