Rescue of non-human primates from advanced Sudan ebolavirus infection with lipid encapsulated siRNA

Emily P. Thi,Amy C. H. Lee,Joan B. Geisbert,Raul Ursic-Bedoya,Krystle N. Agans,Marjorie Robbins,Daniel J. Deer,Karla A. Fenton,Andrew S. Kondratowicz,Ian Maclachlan,Thomas W. Geisbert,Chad E. Mire

Rescue of non-human primates from advanced Sudan ebolavirus infection with lipid encapsulated siRNA

2016

Emily P. Thi
Amy C. H. Lee
Joan B. Geisbert
Raul Ursic-Bedoya
Krystle N. Agans
Marjorie Robbins
Daniel J. Deer
Karla A. Fenton
Andrew S. Kondratowicz
Ian Maclachlan
Thomas W. Geisbert
Chad E. Mire

Treatment with lipid nanoparticles encapsulating siRNAs targeting the viral VP35 gene are able to rescue rhesus macaques infected with a lethal dose of Sudan ebolavirus.

Keywords:

Lethal dose
Sudan ebolavirus
Ebola virus
Viral pathogenesis
Small interfering RNA
Biology
Virology
Ebolavirus
Zaire ebolavirus
Viral load
Immunology
Viral replication
Viremia

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