Asymmetric Cycloisomerization of 1 , n -Enynes Catalyzed by Transition Metals

Asymmetric cycloisomerization catalyzed by transition metals , which possesses highly catalytic activity and good selectivity , is a potential protocol to fulfill the goal of " atom economy " . In recent years , impressive achievements have been made in this area. It becomes one of the most efficient methods to synthesize enantiomeric pure carbon- or heterocyclic compounds. This paper summarized the development of transition metal catalyzed asymmetric cycloisomerization in recent twenty years and briefly reviewed its applications in total synthesis of natural products.