Matched and mixed cap derivatives in the tetracyclic indole class of HCV NS5A inhibitors.

Michael P. Dwyer,Kerry Keertikar,Lei Chen,Ling Tong,Oleg Selyutin,Anilkumar G. Nair,Wensheng Yu,Guowei Zhou,Brian J. Lavey,De-Yi Yang,Michael Wong,Seong Heon Kim,Craig A. Coburn,Stuart B. Rosenblum,Qingbei Zeng,Yueheng Jiang,Bandarpalle B. Shankar,Razia Rizvi,Amin Nomeir,Rong Liu,Sony Agrawal,Ellen Xia,Rong Kong,Ying Zhai,Paul Ingravallo,Ernest Asante-Appiah,Joseph A. Kozlowski

Matched and mixed cap derivatives in the tetracyclic indole class of HCV NS5A inhibitors.

2016

A matched and mixed capping SAR study was conducted on the tetracyclic indole class of HCV NS5A inhibitors to examine the influence of modifications of this region on the overall HCV virologic resistance profiles.

Keywords:

NS5A
Structure–activity relationship
Hepacivirus
Genotype
Indole test
Biochemistry
Stereochemistry
Chemistry
Virology
area under curve

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