Innate Immune Protection against Infectious Diseases by Pulmonary Administration of a Phospholipid-Conjugated TLR7 Ligand

Christina Wu,Brian Crain,Shiyin Yao,Mojgan Sabet,Fitzgerald Lao,Rommel I. Tawatao,Michael Chan,Donald F. Smee,Justin G. Julander,Howard B. Cottam,Donald G. Guiney,Maripat Corr,Dennis A. Carson,Tomoko Hayashi

Innate Immune Protection against Infectious Diseases by Pulmonary Administration of a Phospholipid-Conjugated TLR7 Ligand

2014

Christina Wu
Brian Crain
Shiyin Yao
Mojgan Sabet
Fitzgerald Lao
Rommel I. Tawatao
Michael Chan
Donald F. Smee
Justin G. Julander
Howard B. Cottam
Donald G. Guiney
Maripat Corr
Dennis A. Carson
Tomoko Hayashi

Pulmonary administration of Toll-like receptor (TLR) ligands protects hosts from inhaled pathogens. However, systemic side effects induced by TLR stimulation limit clinical development. Here, a small-

Keywords:

TLR7
Virology
Phospholipid
Immunology
Innate immune system
Immunotherapy
Bacillus anthracis
Lung
Biology
Receptor
Stimulation
Lymphatic system
Immune system
Cytokine
Chemokine

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