Iodine-Mediated Oxidative Annulation for One-Pot Synthesis of Pyrazines and Quinoxalines Using a Multipathway Coupled Domino Strategy.

An efficient iodine-mediated oxidative annulation of aryl acetylenes–arylethenes–aromatic ketones with 1,2-diamines for the synthesis of pyrazines and regioselective synthesis of quinoxalines is presented. A multipathway coupled domino approach has been developed for the one-pot synthesis of 1,4-diazines with high functional group compatibility.