Synthesis of 3,5-dihydroxy-2,4-dimethylheptanoic acid δ-lactone in enantiomerically pure form

Radical-mediated opening of a chiral trisubstituted epoxy alcohol using cp 2 TiCl was followed by diastereoselective reduction of the resulting olefinic diol to build all the chiral centers of 3,5- dihydroxy-2,4-dimethylheptanoic acid δ-lactone 1 in their desired stereochemistries leading to the total synthesis of this highly substituted δ-lactone.