PEPTICINNAMINS, NEW FARNESYL-PROTEIN TRANSFERASE INHIBITORS PRODUCED BY AN ACTINOMYCETE

Kazuro Shiomi,Hong Yang,Junji Inokoshi,Didier Van Der Pyl,Akira Nakagawa,Hideo Takeshima,Satoshi Omura

PEPTICINNAMINS, NEW FARNESYL-PROTEIN TRANSFERASE INHIBITORS PRODUCED BY AN ACTINOMYCETE

1993

Kazuro Shiomi
Hong Yang
Junji Inokoshi
Didier Van Der Pyl
Akira Nakagawa
Hideo Takeshima
Satoshi Omura

Structure of novel farnesyl transferase inhibitor, pepticinnamin E, is elucidated by NMR study. Pepticinnamin E is composed of five amino acids and o-pentenylcinnamic acid, having a molecular weight of 907. C-terminal glycylserine of the compounds is in the cyclized diketopiperazine form.

Keywords:

Microbiology
Enzyme
Farnesyltransferase
Biochemistry
Actinomycetales
Amino acid
Streptomycetaceae
Farnesyl Protein Transferase
Farnesyl Transferase Inhibitor
Stereochemistry
Enzyme inhibitor
Biology

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